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Aβ1-42 exposure reduced the average neurite length in HT22 cells and increased isoform-specific PDE4D expression. A Average neurite length after incubation of HT22 cells with 0.5–1.0 µM Aβ1-42 or GEBR32a and Aβ1-42 (both 1 µM) for 24 h (Dunnett’s post hoc: *P < 0.05; two-tailed t-test: ##P < 0.01; n = 6/condition). B PDE4D isoform mRNA expression after 1 µM Aβ1-42 exposure for 24 h in HT22 (*P < 0.05, **P < 0.01, two-tailed t test; n = 6/condition). Data are presented as mean + SEM
