Table 1.
Vitamin D‡ | ||||||||
---|---|---|---|---|---|---|---|---|
Placebo† (n 55) | All (n 60) | Subset (n 47) | ||||||
Characteristic | % or Mean | n, n/N or sd | % or Mean | n, n/N or sd | % or Mean | n, n/N or sd | P § | P || |
Sex, % and n | ||||||||
Females | 51 | 28 | 56 | 34 | 53 | 25 | 0·36 | 0·54 |
Males | 49 | 27 | 43 | 26 | 47 | 22 | ||
Gestational age at birth, % and n | ||||||||
Preterm (34 to <37 weeks) | 24 | 13 | 12 | 7 | 15 | 7 | 0·33 | 0·09 |
Term (≥37 weeks) | 76 | 42 | 88 | 53 | 85 | 40 | ||
Season at birth, % and n | ||||||||
October–November | 24 | 13 | 32 | 19 | 23 | 11 | 0·04 | 0·46 |
December–February | 56 | 31 | 45 | 27 | 49 | 23 | ||
March–April | 20 | 11 | 23 | 14 | 28 | 13 | ||
Infant anthropometry, mean and sd | ||||||||
Birth weight (kg) | 2·8 | 0·4 | 2·9 | 0·5 | 2·9 | 0·5 | 1·00 | 0·71 |
Length at birth (cm) | 48·1 | 2·2 | 48·5 | 1·8 | 48·5 | 1·9 | 0·78 | 0·28 |
Initiated breast-feeding within 1 h of birth, % and n | 95 | 52 | 95 | 57 | 94 | 44 | 0·35 | 0·91 |
Exclusively breast-fed¶,††, % and n | ||||||||
1 month visit | 76 | 39/51 | 75 | 39/52 | 77 | 30/39 | 0·58 | 0·86 |
2 months visit | 56 | 14/25 | 60 | 18/30 | 58 | 11/19 | 0·76 | 0·77 |
4 months visit | 66 | 19/29 | 55 | 16/29 | 55 | 16/29 | 1·00 | 0·42 |
6 months visit | 28 | 14/50 | 36 | 18/50 | 36 | 15/42 | 1·00 | 0·39 |
Formula use¶,‡‡, % and n | ||||||||
1 month visit | 18 | 9/51 | 17 | 9/52 | 13 | 5/39 | 0·20 | 0·96 |
2 months visit | 24 | 6/25 | 23 | 7/30 | 21 | 4/19 | 0·70 | 0·95 |
4 months visit | 24 | 7/29 | 24 | 7/29 | 24 | 7/29 | 1·00 | 1·00 |
6 months visit | 48 | 24/50 | 42 | 21/50 | 40 | 17/42 | 0·71 | 0·55 |
Animal-source foods¶,§§, % and n/N | ||||||||
1 month visit | 0 | 0/51 | 0 | 0/52 | 0 | 0/39 | – | – |
2 months visit | 0 | 0/25 | 7 | 2/30 | 11 | 2/19 | 0·52 | 0·19 |
4 months visit | 0 | 0/29 | 7 | 2/29 | 7 | 2/29 | 1·00 | 0·15 |
6 months visit | 16 | 8/50 | 16 | 8/50 | 19 | 8/42 | 0·32 | 1·00 |
Usually or always swaddled outside the home, % and n/N | ||||||||
1 month visit | 98 | 50/51 | 98 | 50/51 | 97 | 37/38 | 1·00 | 1·00 |
2 months visit | 68 | 17/25 | 70 | 21/30 | 74 | 14/19 | 0·69 | 0·87 |
4 months visit | 24 | 7/29 | 31 | 9/29 | 31 | 9/29 | 1·00 | 0·56 |
6 months visit | 6 | 3/50 | 4 | 2/50 | 2 | 1/42 | 0·30 | 0·65 |
Expressed preference to expose infant to sunlight, % and n/N | ||||||||
1 month visit | 92 | 47/51 | 94 | 47/50 | 92 | 34/37 | 0·56 | 0·72 |
2 months visit | 64 | 16/25 | 60 | 18/30 | 58 | 11/19 | 1·00 | 0·76 |
4 months visit | 59 | 17/29 | 79 | 23/29 | 79 | 23/29 | 1·00 | 0·09 |
6 months visit | 90 | 45/50 | 68 | 34/50 | 67 | 28/42 | 1·00 | 0·01 |
There was one set of twins in the placebo group, hence, there were fifty-five infants born to fifty-four mothers in the placebo group.
Vitamin D ‘all’ group included data for all infants with any 25-hydroxyvitamin D (25(OH)D) available in the first 6 months of life. The ‘subset’ excluded data for thirteen infants who did not contribute 25(OH)D data at or beyond 4 months.
P values for differences between ‘all’ and ‘subset’ vitamin D groups were based on χ 2 and Fisher’s exact tests for proportions or linear regression for differences in means.
P values for differences between placebo and ‘all’ vitamin D groups were based on χ 2 and Fisher’s exact tests for proportions or linear regression for differences in means.
Specified postnatal visits: 1 month (2 to 40 d), 2 months (46 to 81 d), 4 months (84 to 138 d) and 6 months (168 to 203 d).
Exclusive breast-feeding was defined as reported breast-feeding in the past 24 h (yes/no) and a lack of formula or complementary foods previously ever reportedly fed to the infant.
Data on recent formula use (yes/no) was available for n 98 (n 47 in the placebo group and n 51 in the vitamin D group). Infant ‘formula’ type often unspecified by caregiver; may include powdered fortified milk beverages not intended for infants.
Reported infant consumption of animal-source foods (yes/no), including fish, animal milk (other than ‘infant formula’), egg, meat or liver.