Table 2. Performance of Candidate Predictors of Mortality in Neonatal Sepsis.

Summary of candidate predictors of mortality. IL-8 is superior to PERSEVERE II with improved sensitivity, specificity, negative predictive value, and area under the curve. nPERSEVERE is superior to IL-8 with improved specificity, + likelihood ratio, and area under the curve.

Characteristic	PERSEVERE	IL-8	nPERSEVERE
Sensitivity (95% CI)	67% (35–88%)	100% (70–100%)	100% (71–100%)
Specificity (95% CI)	59% (45–72%)	65% (51–77%)	85% (73–93%)
NPV (95% CI)	91% (76–97%)	100% (89–100%)	100% (92–100%)
PPV (95% CI)	23% (11–42%)	35% (19–54%)	56% (33–77%)
+ Likelihood Ratio	1.6	2.9	7
AUC (95% CI)	0.65 (0.46–0.84)	0.87 (0.77–0.98)	0.95 (0.89–1.00)
The Fisher’s Exact test p value	0.27	0.0003	<0.0001