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. 2023 Jun 13;5(3):zcad028. doi: 10.1093/narcan/zcad028

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© The Author(s) 2023. Published by Oxford University Press on behalf of NAR Cancer.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — TADs in RMS. (A, B) Subtype-specific TADs are shown on chromosome 1 for Rh4, Rh30, RD and SMS-CTR with a colorimetric interaction intensity scale (shown, left) and subtypes (shown, right). (C) CTCF-bounded loop domains are shown with interaction intensity plotted in blue above CTCF ChIP-seq data for each cell line in green. Looping interactions are highlighted in yellow with arcs connecting the loop anchors on the ChIP-seq plots. (D) The most highly enriched motifs (top sequences, left; top TFs, right) at TAD boundaries are indicated for Rh4, Rh30, RD and SMS-CTR. (E) Tumor-specific genes associated with differential TADs in our RMS cell models are indicated.