Table 3.
Accumulated DDD/1,000 patient-days in Intensive Care Units of the city of São Paulo, Brazil (January 2017 ‒ December 2020).
| Anti-microbial | Pre-pandemic period (January 2017 ‒ February 2020) Accumulate DDD/1,000 patient-days | Pandemic period (March ‒ December 2020) |
||
|---|---|---|---|---|
| Non-COVID-19 ICU | COVID-19 ICU | p-value | ||
| Polymyxins | 6.43 | 6.66 | 146.20 | <0.001 |
| Carbapenem | 19.79 | 19.14 | 20.50 | 0.53 |
| Glycopeptide | 18.07 | 20.10 | 40.14 | <0.001 |
| β-lactamase inhibitor + penicillin | 14.62 | 15.04 | 6.24 | <0.001 |
| Ceftriaxone | 22.30 | 22.03 | 25.74 | 0.13 |
| Antipseudomonal cephalosporins | 2.91 | 2.25 | 1.33 | <0.001 |
| Quinolones | 4.69a | 3.52 | 5.20 | 0.008 |
| Azoles | 5.89 | 4.86 | 16.25 | <0.001 |
| Echinocandins | 3.00 | 4.13 | 27.63 | <0.001 |
a
< 0.05 when compared to the pandemic period.