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. 2023 Jun 13. Online ahead of print. doi: 10.1016/j.vaccine.2023.06.032

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© 2023 Published by Elsevier Ltd.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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SARS-CoV-2 live virus nAb activity of maternal and cord blood sera by study group and study visit. Pregnant participants received a 2-dose series of an mRNA vaccine (top – Pfizer, middle – Moderna) or a booster mRNA vaccine (bottom panel). Sera derived from maternal blood collected pre- and post-vaccination and at delivery, and cord blood, were evaluated for neutralization of D614G, Delta, and Omicron (BA.1) variants. Each point represents the GMT ID50 from two duplicates per specimen (within the same assay run). A value equivalent to half the lower limit of detection (LLOD = 20) was assigned to observations with no detectable response. A specimen was considered as having a positive response if at least one of the duplicates was above the LLOD. Box plots represent median (horizontal line within the box) and interquartile range. Response rate (% with responses > 20 ID50), GMT, and GMT fold reduction compared to D614G are displayed at the top of each panel.