Table 4.
Antibody Transfer Ratios and Cord Blood and Maternal Sera Levels at Delivery for Primary 2-Dose and Booster Groups
| Lab Assessment | Group | Transfer RatioMedian (IQR) | Cord Blood SerumGMT(95% CI) | Maternal SerumGMT(95% CI) |
|---|---|---|---|---|
| Spike IgG BAU/mL | Primary | 1.77 (1.38, 2.25) | 500.5(424.1, 590.7) | 313.8(260.7, 377.8) |
| Booster | 1.55 (1.17, 1.98) | 3290.4(2713.6, 3989.9) | 2200.6(1764.9, 2743.8) | |
| RBD IgG BAU/mL | Primary | 1.76 (1.33, 2.15) | 673.1(564.5, 802.6) | 428.6(351.9, 522.1) |
| Booster | 1.58 (1.05, 1.93) | 5005.7(4126.5, 6072.1) | 3382.9(2703.7, 4232.86) | |
| D614G live virus nAb ID50* | Primary | 1.10 (0.76, 1.89) | 96.4(80.2, 115.9) | 83.4(65.4, 106.4) |
| Booster | 1.78 (1.12, 2.25) | 742.5(588.5, 936.8) | 446.4(342.1, 582.5) | |
| Delta live virus nAb ID50* | Primary | 1.10 (1.00, 1.69) | 52.1(42.3, 64.2) | 39.0(30.9, 49.2) |
| Booster | 1.74 (1.06, 2.38) | 644.5(507.5, 818.4) | 390.2(299.2, 508.9) | |
| Omicron live virus nAb ID50* | Primary | 1.00 (1.00, 1.00) | 13.8(12.2, 15.6) | 13.5(11.9, 15.3) |
| Booster | 1.69 (1.00, 2.75) | 109.2(81.6, 146.1) | 60.2(43.6, 83.1) | |
| Pseudotyped WT nAb IC50* | Primary | 2.36 (1.96, 2.84) | 220.8(183.5, 265.7) | 93.4(77.3, 112.9) |
| Booster | 1.79 (1.46, 2.20) | 941.4(735.7, 1204.7) | 512.5(399.1, 658.3) |
*
All data are included in the calculation of the transfer ratio including those below the LLOQ of the assay.