Table 2.
Transplantation outcomes according to CD34＋ cell dose
| Lower CD34＋ dose
(＜6×106/kg) |
Higher CD34＋ dose
(≥6×106/kg) |
p-value | |
|---|---|---|---|
| Number of patients | 165 (64.7) | 90 (35.3) | |
| Median follow-up, days (range) | 534 (8-4962) | 636 (6-6381) | 0.168 |
| Median stem cell infusion, (range) | |||
| CD34＋ ×106/kg | 3.94 (0.46-6.00) | 7.54 (6.01-20.6) | ＜0.001 |
| MNC×108/kg | 6.91 (0.36-12.70) | 9.65 (3.68-25.12) | ＜0.001 |
| CD3＋ ×108/kg | 2.70 (0.05-7.45) | 3.10 (1.25-10.01) | 0.001 |
| Engraftment | |||
| Neutrophil＞500 mm3 | 157 (95.2) | 84 (94.4) | 0.810 |
| Platelet＞20,000/mm3 | 150 (90.9) | 77 (85.6) | 0.159 |
| Median time to engraftment, days | |||
| Neutrophil＞500/mm3 | 13 (8-30) | 12 (9-24) | 0.791 |
| Platelet＞20,000/mm3 | 13 (8-121) | 12 (7-161) | 0.672 |
| aGVHD | 0.594 | ||
| II-IV | 65 (39.4) | 39 (43.0) | |
| III-IV | 16 (9.7) | 12 (13.3) | |
| cGVHD, Seattle | 0.786 | ||
| Classic chronic | 44 (26.7) | 26 (28.9) | |
| Overlap | 17 (10.3) | 10 (11.1) | |
| cGVHD, NIH 2005 | 0.821 | ||
| mild | 36 (21.8) | 20 (22.2) | |
| moderate | 30 (18.2) | 20 (22.2) | |
| severe | 1 (0.6) | 0 | |
| Cause of Death | 100 (60.1) | 58 (64.4) | 0.712 |
| Relapse | 37 (22.4) | 24 (26.7) | |
| Infection | 29 (17.6) | 12 (13.3) | |
| GVHD | 18 (10.9) | 11 (12.2) | |
| VOD | 10 (6.1) | 9 (10.0) | |
| Others | 6 (3.6) | 2 (2.2) |
Others: 3 patients died of cardiac arrest, 2 patients died of brain hemorrhage, 1 patient died of pulmonary hemorrhage, 1 patient died of malnutrition, 1 patient died of acute renal failure.
MNC, mononuclear cell; aGVHD, acute graft-versus-host disease; cGVHD, chronic graft-versus-host disease; VOD, veno-occlusive disease.