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. 2023 May 29;12(5):1093–1107. doi: 10.21037/tlcr-23-258

Figure 3.

Figure 3

Blocking C5aR signaling in combination with RT could produce synergistic effect in antitumor efficacy. (A) Mice were inoculated subcutaneously with LLC tumor cells and treated with 8 Gy of local RT daily for 3 times. After RT, mice were intraperitoneally injected with 5.0 mg/kg/day C5aR1 inhibitor (W-54011) every other day. (B) The body weight change of LLC tumor-bearing mice in RT+W-54011 group, RT group, W-54011 group and control group (n=4 or 5 mice). (C) Representative images of tumors from mice of every group collected on day 24. (D,E) Tumor growth kinetics and (F) tumor weight of LLC tumor-bearing mice in RT+W-54011 group, RT group, W-54011 group and control group (n=4 or 5 mice). *, P<0.05; **, P<0.01; ***, P<0.001; ****, P<0.0001. RT, radiotherapy; Con, control; LLC, Lewis lung carcinoma.