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In a transgenic rodent model of vasculopathy-induced pain, noradrenergic fibre innervation into the dorsal is unchanged. Representative image examples of noradrenergic DβH-positive processes in the lumbar dorsal horn of (A) WT and (B) VEGFR2KO mice (scale bar = 10 µm). There was no change in DβH immunoreactivity within the dorsal horn [(C) area, WT mean ± SEM: 22.74 ± 0.99 A.U. vs VEGFR2KO mean ± SEM: 21.26 ± 1.410 A.U.; (D) integrated density, N = 5 per group].
