Table 2.

Organ system toxicity and the associated chemotherapeutic agent

Organ system toxicity	Chemotherapeutic agent
Pulmonary	Antitumor antibiotics, alkylating agents, antimetabolites, plant alkaloids
Cardiovascular	Antitumor antibiotics (anthracyclines and mitomycin), plant alkaloids, alkylating agents (cyclophosphamide, ifosfamide, cisplatin, busulfan, carmustine, chlormethine), antimetabolite (5‐FU)
Hepatobiliary	Alkylating (nitrosoureas, platinums, nitrogen mustards) antimetabolites (5-FU), antitumor antibiotics, plant alkaloids
Renal	Antitumor antibiotics, antimetabolites, alkylating agents