Table 2. Antifungal Activity of Compounds 1–3a.
| compound | Mw | E. coli BW25113 (WT) | E. coli JW5503-1 (tolC) | S. aureus ATCC 29213 | C. albicans ATCC 90028 | C. albicans #1186858 (azole R) | C. albicans #1181444 (echinocandin R) | C. kruse ATCC 6258 | C. parapsilosis ATCC 22019 | C. tropicalis ATCC 13803 | C. glabrata ATCC MYA-2950 | A. fumigatus ATCC MYA-3626 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 433.2 | >20 | >20 | >20 | 0.08 | 0.16 | 0.08 | 0.16 | 0.16 | 0.08 | 0.08 | 0.16 |
| 2 | 433.2 | >20 | >20 | >20 | 1.25 | 2.5 | 1.25 | 1.25 | 1.25 | 1.25 | 1.25 | 2.5 |
| 3 | 405.4 | >20 | >20 | >20 | 0.16 | 0.3 | 0.16 | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 |
| fluconazole | 306.3 | >64 | >64 | >64 | 0.25 | >64 | 0.5 | 32 | 2 | 0.5 | 8 | >64 |
| micafungin | 1270.3 | >4 | >4 | >4 | 0.03 | 0.03 | 1 | 0.12 | 0.5 | 0.06 | 0.02 | 0.06 |
a
MIC values are presented in mg/L. Strains tested were efflux-competent WT E. coli BW25113, tolC efflux deficient E. coli JW5503-1, S. aureus ATCC 29213, C. albicans ATCC 90028, azole-resistant C. albicans isolate #1186858 (JMI Laboratories), echinocandin-resistant C. albicans isolate #1181444 (JMI Laboratories), C. krusei ATCC 6258, C. parapsilosis ATCC 22019, C. tropicalis ATCC 13803, C. glabrata ATCC MYA-2950, and A. fumigatus ATCC MYA-3626. Fluconazole and micafungin were run as controls.