Alignment of LmPAB1 with PAB1 homologues. The open reading frame of LmPAB1 is aligned (CLUSTALV; 61) against PAB1 homologues from Human (H.s) [genpept accession no. g129617], S.cerevisae (S.c) [genpept accession no. P04147] and T.cruzi (T.c) [GenBank accession no. U06070]. Coloured boxes delineate the four N-terminal RNA binding domains (RBD1, blue, amino acids 22–105; RBD2, red, amino acids 106–193; RBD3, green, amino acids 194–288; RBD4, orange, amino acids 303–386) and the conserved C-terminal domain (purple, amino acids 498–560). RNP1 motifs are highlighted (asterisks) and potential sites of phosphorylation indicated (circles) (35).