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. Author manuscript; available in PMC: 2023 Jun 14.
Published in final edited form as: Mol Pharm. 2013 Nov 15;10(12):4452–4461. doi: 10.1021/mp400290u

Figure 4.

Figure 4

Tumor Saturation Dose Evaluation of 125I-1 in PC-3 Tumor-bearing Mice: 1.7 mg/kg (blue), 23.2 mg/kg (red), 70.9 mg/kg (purple), and 111.3 mg/kg (green). (A) Representative transaxial SPECT/CT images of PC3 tumor in SCID mice (48 h p.i.). Tumors are indicated by white arrows. (B) Tumor uptake of 125I-1 versus tumor size. Tumors smaller than 100 mm3 were selected for the evaluation. (Number of tumors evaluated in each group: 7 (1.7 mg/kg); 5 (23.2 mg/kg); 8 (70.9 mg/kg); 5 (111.3 mg/kg). (C) Tumor uptake levels of the 4 dosing groups in tumors smaller than 40 mm3. (Number of tumors evaluated in each group: 4 (1.7 mg/kg); 5 (23.2 mg/kg); 8 (70.9 mg/kg); 4 (111.3 mg/kg)). SUV is standardized uptake value of the labeled prodrug.