Table 3.
The target AUC compliance of polymyxin B
| HD group n, % |
LD group n, % |
RR (95% CI) | RD (95% CI) | p value | |
|---|---|---|---|---|---|
| ssAUC0–24 between 50–100 mg · h/L at the second dose, % | 54.1 (80/148) | 26.8 (42/157) | 2.021 (1.499, 2.723) | 27.30 (16.37, 37.35) | < 0.001 |
| ssAUC0–24 > 100 mg · h/L at the second dose, % | 8.8 (13/148) | 5.1 (8/157) | 1.724 (0.736, 4.040) | 3.69 (− 2.17, 9.88) | 0.204 |
| ssAUC0–24 between 50 and100 mg · h/L at the seventh dose, % | 63.8 (81/127) | 38.9 (51/131) | 1.638 (1.274, 2.106) | 24.85 (12.68, 35.99) | < 0.001 |
| ssAUC0–24 > 100 mg · h/L at the seven dose, % | 11.8 (15/127) | 3.1 (4/131) | 3.868 (1.319, 11.340) | 8.76 (2.35, 15.77) | 0.007 |
| ssAUC0–24 between 50–100 mg · h/L at final, % | 64.6 (82/127) | 47.3 (62/131) | 1.364 (1.093, 1.703) | 17.24 (5.12, 28.65) | 0.005 |
| ssAUC0–24 > 100 mg · h/L at final, % | 9.5 (12/127) | 3.1 (4/131) | 3.095 (1.025, 9.343) | 6.40 (0.37, 13.00) | 0.033 |
n: sample size. HD: high dose. LD: low dose. RR: risk ratio. RD: risk difference