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. 2023 Jun 12;21:383. doi: 10.1186/s12967-023-04206-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — The biodistribution of DiR-labeled CAR-Exos via inhalation in vivo. A The biodistribution of CAR-Exos in vivo via intravenous injection or inhalation. B The quantification of DiR intensity from A. C The intensity of inhaled CAR-Exos at different time points in vivo. D The quantification of DiR intensity at different time points. E The intensity of inhaled CAR-Exos at different concentrations of exosomes in vivo. F The quantification of DiR intensity at different doses. Data are presented as the mean ± SD of three biological replicates