Fig. 5.

The therapeutic efficacy of PTX@CAR-Exos in orthotopic lung tumor-bearing mice. A The designed diagram for evaluating the efficacy of PBS, T-Exos, CAR-Exos, or PTX@CAR-Exos treated orthotopic lung tumor-bearing mice. Mice were given inhaled therapy via nebulizer for 2 weeks, starting on day 7 after establishment of the orthotopic model; IVIS imaging was performed on days 14 and 21 post implantation. B Respective bioluminescence images of MSLN-LLC cells in mice on days 7, 14, and 21 post implantation. C Statistical analysis of the signal intensity from B. D Survival analysis of tumor bearing mice after different treatments. E Representative images of tumor nodules in different groups and H&E-stained slice images of the lungs. Scale bar: 100 μm. Data are presented as the mean ± SD of three biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, ns: not significant