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. 2023 Jun 12;15(1):2221098. doi: 10.1080/19490976.2023.2221098

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 4. — Change of the bile acid profile in different mice. (a) Composition of the liver bile acid pool in LL, LKO, and AKO mice. (b-c): Fold change of total bile acid and 12-OH bile acids in the liver (b) and serum (c) between the LL and LKO group. (d) Ratio of 12-OH bile acids to non-12-OH bile acids in the liver and serum of LL and LKO mice. (e) Content of serum C4 in LL and LKO mice. *: P < 0.05, **: P < 0.01, ***: P < 0.001.