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. 2023 Jun 12;15(1):2221098. doi: 10.1080/19490976.2023.2221098

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 5. — Analysis of bile acid metabolism regulation by hepatic GH signaling. (a) Expression level of genes related to bile acid metabolism in the liver of LL and LKO mice. (b-c) Expression level of Cyp8b1 in rhGH treated HFD fed mice (b) and HepG2 cells (c). (d) Expression level of hepatic Fxr and Shp in LL and LKO mice. (e) Expression level of hepatic Fxr and its downstream Shp and MafG in LKO mice after GW4064 treatment. (f) Expression level of hepatic Cyp8b1 in the GW4064 treated LKO mice. *: P < 0.05, **: P < 0.01, ***: P < 0.001.