Figure 3.

Pharmacokinetic analysis of HZ0412a in cynomolgus monkeys. The administration of HZ0412a (1 or 5 mg/kg) was achieved by subcutaneous injection. One male (M) and one female (F) animals were injected at each dose. At indicated time points, blood was collected by venipuncture into tubes without an anticoagulant. The serum HZ0412a levels were measured by ELISA as described in section Materials and Methods. The green dash line indicates the serum level of 5 μg/ml. Based on our previous in vitro data, serum HZ0412a levels over 5 μg/ml are expected to be able to inhibit most of the IL-6 effects.