Table 2.
Variants associated with eGFR in diabetes.
| SNP | Reported gene | Diabetes population | Phenotype | N total | P-value | EA | NEA | Beta | Refs |
|---|---|---|---|---|---|---|---|---|---|
| rs12917707 a,b | UMOD | T1D + T2D | log eGFR per allele | 11,522 | 2.5 × 10−8 | T | G | 0.0266 | (19, 50, 75) |
| rs11864909 a | UMOD | T1D + T2D | ml/min/1.73 m2 | 23,708 | 2.3 × 10−12 | T | C | 2.11 | (19) |
| rs1974990 | SSB | T1D + T2D | ml/min/1.73 m2 | 13,158 | 4.8 × 10−8 | G | T | 4.07 | (19) |
| rs10224002 a | PRKAG2 | T1D + T2D | ml/min/1.73 m2 | 22,165 | 2.7 × 10−8 | A | G | 2.01 | (19, 50) |
| rs267738 a | CERS2 | Any | log eGFR per allele | 176,573 | 2.7 × 10−8 | T | G | −0.0065 | (76) |
| rs4665972 a | SNX17 | Any | log eGFR per allele | 170,721 | 3.3 × 10−9 | T | C | 0.0057 | (76) |
| rs10206899 a | ALMS1P | Any | log eGFR per allele | 143,419 | 1.6 × 10−8 | T | C | −0.0068 | (76) |
| rs1047891 a | CPS1 | Any | log eGFR per allele | 170,741 | 5.6 × 10−12 | A | C | −0.007 | (76) |
| rs4663171 | SH3BP4 | Any | log eGFR per allele | 170,901 | 8.8 × 10−9 | A | T | −0.0072 | (76) |
| rs28817415 a | SHROOM3 | Any | log eGFR per allele | 176,910 | 9.9 × 10−26 | T | C | −0.0091 | (76) |
| rs10857147 a | FGF5 | Any | log eGFR per allele | 170,848 | 2.4 × 10−10 | A | T | −0.0061 | (76) |
| rs434215 a,b | TPPP | Any | log eGFR per allele | 119,397 | 3.5 × 10−19 | A | G | −0.0119 | (76) |
| rs3812036 a | SLC34A1 | Any | log eGFR per allele | 170,458 | 2.1 × 10−12 | T | C | −0.0073 | (76) |
| rs34246779 a | HMGN4 | Any | log eGFR per allele | 172,626 | 1.1 × 10−8 | A | G | −0.0091 | (76) |
| rs3101824 a,b | SLC22A2 | Any | log eGFR per allele | 176,569 | 3.6 × 10−23 | T | C | −0.0143 | (76) |
| rs11761603 a | UNCX | Any | log eGFR per allele | 168,668 | 4.8 × 10−15 | T | C | 0.0075 | (76) |
| rs6464165 a | PRKAG2 | Any | log eGFR per allele | 136,252 | 4.0 × 10−21 | T | C | 0.0107 | (76) |
| rs9314272 a | STC1 | Any | log eGFR per allele | 177,021 | 9.4 × 10−10 | A | G | −0.0054 | (76) |
| rs7033278 a | PIP5K1B c | Any | log eGFR per allele | 176,480 | 1.3 × 10−10 | T | C | 0.0062 | (76) |
| rs80282103 a | LARP4B | Any | log eGFR per allele | 176,591 | 6.8 × 10−11 | A | T | 0.0109 | (76) |
| rs55917128 | LOXL4 | Any | log eGFR per allele | 176,998 | 4.6 × 10−8 | T | C | −0.0048 | (76) |
| rs963837 a,b | DCDC5 | Any | log eGFR per allele | 170,722 | 2.4 × 10−34 | T | C | −0.0108 | (76) |
| rs2004649 a | MAP3K11 | Any | log eGFR per allele | 176,918 | 6.1 × 10−10 | A | G | −0.0055 | (76) |
| rs10899482 a | GAB2 | Any | log eGFR per allele | 177,039 | 1.2 × 10−8 | A | C | −0.0058 | (76) |
| rs2461700 a | GATM | Any | log eGFR per allele | 177,144 | 1.5 × 10−15 | T | C | 0.008 | (76) |
| rs17631603 a | WDR72 | Any | log eGFR per allele | 177,042 | 6.6 × 10−15 | A | G | 0.0068 | (76) |
| rs11636251 a | NRG4 | Any | log eGFR per allele | 171,081 | 1.9 × 10−14 | T | C | −0.0069 | (76) |
| rs77924615 a,b | UMOD/PDILT | Any | log eGFR per allele | 170,741 | 1.9 × 10-106 | A | G | 0.0234 | (76) |
| rs9895661 a | BCAS3 | Any | log eGFR per allele | 176,461 | 6.7 × 10−10 | T | C | 0.0066 | (76) |
| rs8096658 a | NFATC1 | Any | log eGFR per allele | 167,173 | 1.6 × 10−12 | C | G | 0.0067 | (76) |
| rs6015028 a | PCK1 | Any | log eGFR per allele | 176,558 | 1.4 × 10−9 | A | T | −0.0071 | (76) |
| rs1882961 a,b | NRIP1 | Any | log eGFR per allele | 176,630 | 3.6 × 10−14 | T | C | −0.0073 | (76) |
| rs9607518 a | MAFF | Any | log eGFR per allele | 170,649 | 2.2 × 10−8 | T | C | −0.0049 | (76) |
SNP: Variant rs-identifier. EA: Effect allele. NEA: non-effect allele. Beta: effect size beta estimate. Refs: If multiple references are given, then the data in other columns for the same locus are taken from the first listed reference.
a
Associated with eGFR also in the general population.
b
Significant effect size difference between individuals with and without diabetes.