Table 3.
Variants associated with albuminuria in diabetes.
| SNP | Reported gene | Diabetes population | Phenotype | N | P-value | EA | NEA | Beta | Refs |
|---|---|---|---|---|---|---|---|---|---|
| rs10011025 | GLRA3 | T1D | log10 AER | 1,925 | 1.5 × 10−9 | G | A | 0.21 | (25, 81) |
| rs59825600 | KAZN | Any | sd of log(UACR) | 40,668 | 3.6 × 10−8 | A | G | −0.075 | (82) |
| rs6688849a | FOXD2 | Any | sd of log(UACR) | 51,215 | 4.1 × 10−9 | A | G | −0.049 | (82) |
| rs780093 a | GCKR | Any | sd of log(UACR) | 51,515 | 1.5 × 10−13 | T | C | 0.049 | (82) |
| rs6706313 | MIR4432HG-BCL11A | Any | sd of log(UACR) | 51,162 | 2.8 × 10−8 | A | G | −0.041 | (82) |
| rs17137004 | FOXP2 | Any | sd of log(UACR) | 51,294 | 2.7 × 10−8 | A | G | −0.036 | (82) |
| rs74375025 a | CUBN | Any | sd of log(UACR) | 50,641 | 1.1 × 10−24 | A | G | 0.106 | (82) |
| rs4258701 | CDH2 | Any | sd of log(UACR) | 51,328 | 1.1 × 10−8 | T | C | 0.039 | (82) |
| rs149131600 a | HPN | Any | sd of log(UACR) | 46,939 | 3.5 × 10−8 | T | C | 0.050 | (82) |
SNP: Variant rs-identifier. EA: Effect allele. NEA: non-effect allele. Beta: effect size beta estimate. Refs: If multiple references are given, then the data in other columns for the same locus are taken from the first listed reference. AER, albumin excretion rate. UACR, urinary albumin-to-creatinine ratio.
a
Significant also in the general population, but with larger effect in diabetes.