Table 3.

In vitro metabolism determination of four deuterated analogs of ND-11176 (2) in mouse, marmoset and human hepatic microsomes.

Cmpd	Structure	Mouse		Marmoset		Human
		Half-life (min)	CLint (ml/min/g protein)	Half-life (min)	CLint (ml/min/g protein)	Half-life (min)	CLint (ml/min/g protein)
30		20	70	12	116	53	26
52		16	87	12	116	46	30
55		33	42	14	98	36	38
57		18	78	23	60	43	32
2		15	92	10	141	30	46