Table 1 –

Multivariable Cox proportional-hazard model for prediction of distant metastasis and prostate cancer–specific mortality stratified by treatment for men with radiorecurrent high-risk prostate cancer

	Distant metastasis		Prostate cancer–specific mortality
	HR (95% CI)	p value	HR (95% CI)	p value
External beam radiation therapy
Interval to biochemical failure ^a	0.84 (0.78–0.89)	<0.001	0.72 (0.63–0.81)	<0.001
Age at treatment (per 5-yr increment)	1.01 (0.93–1.09)	0.8	1.04 (0.94–1.16)	0.4
ln(iPSA)	0.88 (0.77–1.01)	0.064	0.85 (0.7–1.03)	0.095
Gleason grade group (reference: GG1) ^b
GG 2	1.32 (0.62–2.81)	0.5	5.14 (0.64–41.22)	0.12
GG 3	2.03 (0.95–4.30)	0.066	9.16 (1.17–71.85)	0.035
GG 4	1.89 (0.96–3.69)	0.064	7.94 (1.06–59.14)	0.043
GG 5	2.35 (1.19–4.65)	0.014	17.24 (2.33–127.45)	0.005
Clinical T stage (reference: cT1c) ^c
cT2a	1.50 (0.95–2.36)	0.083	1.08 (0.56–2.05)	0.8
cT2b	1.00 (0.64–1.57)	>0.9	0.91 (0.46–1.8)	0.8
cT2c	0.91 (0.56–1.48)	0.7	0.77 (0.37–1.61)	0.5
cT3a	1.33 (0.88–2.03)	0.18	1.10 (0.58–2.08)	0.8
cT3b	1.22 (0.77–1.94)	0.4	1.19 (0.62–2.28)	0.6
cT4	2.27 (1.22–4.23)	0.010	1.87 (0.84–4.13)	0.12
External beam radiation therapy + BT
Interval to biochemical failure ^a	0.87 (0.77–0.99)	0.031	0.81 (0.69–0.94)	0.008
Age at treatment (per 5-yr increment)	1.00 (0.85–1.18)	>0.9	0.96 (0.79–1.17)	0.7
ln(iPSA)	0.83 (0.60–1.15)	0.3	0.78 (0.53–1.15)	0.2
Gleason grade group (reference: GG1) ^b
GG 2	0.29 (0.05–1.78)	0.18	0.46 (0.08–2.64)	0.4
GG 3	-	--	-	-
GG 4	0.28 (0.09–0.91)	0.035	0.17 (0.04–0.73)	0.017
GG 5	0.33 (0.1–1.05)	0.060	0.54 (0.14–2.11)	0.4
Clinical T stage (reference: cT1c) ^c
cT2a	0.35 (0.12–1.01)	0.053	0.24 (0.06–1)	0.050
cT2b	0.73 (0.33–1.61)	0.4	0.69 (0.28–1.68)	0.4
cT2c	0.63 (0.24–1.65)	0.3	0.88 (0.32–2.47)	0.8
cT3a	0.86 (0.4–1.82)	0.7	1.37 (0.64–2.96)	0.4
cT3b	0.26 (0.07–0.97)	0.045	0.4 (0.1–1.68)	0.2
cT4	-	--	-	-

PC = prostate cancer; BT = brachytherapy boost; HR = hazard ratio; CI = confidence interval; GG = grade group; ln(iPSA) = natural log of initial prostate-specific antigen.

Per 1-yr increment.

Per grade group increment.

Per cT stage increment.