Fig. 2.

– Cancer-relevant gene mutations correlate directly across the spectrum of metastatic castration-sensitive prostate cancer. An oncoprint of metastatic categories shows that the mutation frequency increases with increasing metastatic tendency and burden, including TP53 (p = 0.01), WNT (p = 0.04), and cell cycle (p = 0.004) genes. The metachronous oligometastatic (Oligomet) category had a frequency of driver mutations intermediate between those of BCR (micrometastatic) and metachronous polymetastatic (Polymet). The frequency of mutations in the Polymet category tended to mirror or were higher than those of the de novo metastatic category (no significant differences according to p values).