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. 2023 Jun 13;3(6):1026–1040. doi: 10.1158/2767-9764.CRC-22-0415

FIGURE 4.

FIGURE 4

Immunologic characteristics of immune subtypes based on TIL profiling. Numbers of cases analyzed using RNA-seq were LUAD (n = 72; Cold, n = 14; Myeloid, n = 33; CD8, n = 25) and LUSQ (n = 44; Cold, n = 10; Myeloid, n = 18; CD8, n = 16). A, Expression of IFNγ and granzyme B as a function of immune subtype. B, Scores of type I IFN and IFNγ signatures as a function of immune subtype. Expression levels and scores were obtained from RNA-seq. C, Boxplots showing Shannon entropies of canonical TCR repertoires (TCRα, TCRβ, TCRδ, and TCRγ) as a function of immune subtype. D, Expression of immune checkpoint molecules as a function of immune subtype. PDCD1, CD274, HAVCR2, and LAG3 expression levels are obtained from RNA-seq. E and F, Radar plots showing immunograms of immune subtypes; axes were generated with the IGS. Median IGS is plotted in red. LUAD (E). LUSQ (F).