Figure 1.
Manhattan plot of stage I gene variants associated with idiopathic pulmonary fibrosis survival. Each dot represents a gene variant, arranged on the x-axis by chromosome. Variants falling above the blue line, which corresponds to P < 5 × 10−5, are considered to reach nominal significance, whereas those falling above the red line, which corresponds to P < 5 × 10−8, are considered to reach genome-wide significance. All variants crossing the nominal significance threshold were advanced for stage II testing. Chr = chromosome; DAZAP1 = deleted in azoospermia-associated protein 1; PCSK6 = proprotein convertase subtilisin/kexin type 6; RNU6 = U6 small nuclear RNA; SUCLG1 = succinate-CoA ligase GDP/ADP-forming subunit α; UBE2Q2 = ubiquitin-conjugating enzyme E2Q family member 2.