Table 1.
Baseline Characteristics and Outcomes of Stage I and II Data Sets
| Characteristic | Stage I (n = 1,481) |
Stage II (n = 397) |
||
|---|---|---|---|---|
| United States* (n = 318) |
United Kingdom† (n = 565) |
UUS‡ (n = 598) |
Vanderbilt§ | |
| Age, yr, mean (SD) | 67.3 (8.9) | 72.1 (8.4) | 69.8 (8.3) | 65.7 (9.0) |
| Male sex, n (%) | 234 (73.6) | 403 (71.3) | 449 (75.1) | 295 (74.3) |
| FVC, % predicted, mean (SD) | 62.7 (17.9) | 77.7 (18.5) | 70.2 (18.6) | 65.0 (16.1) |
| DlCO, % predicted, mean (SD) | 36.7 (14.6) | 43.3 (14.3) | 39.9 (14.6) | 39.1 (13.5) |
| GAP stage, n (%) | ||||
| I | 72 (23.1) | 106 (35.2) | 135 (24.2) | 115 (29.8) |
| II | 149 (47.8) | 144 (47.8) | 286 (51.4) | 201 (52.1) |
| III | 91 (29.2) | 51 (16.9) | 136 (24.4) | 70 (18.1) |
| Death, n (%) | 189 (59.4) | 366 (64.8) | 257 (43.0) | 202 (50.9) |
| Transplantation, n (%) | 52 (16.4) | 2 (0.4) | 26 (4.4) | 32 (8.1) |
| Death or transplantation, n (%) | 241 (75.8) | 366 (64.8) | 283 (47.3) | 234 (58.9) |
| Median survival, mo (IQR) | 39.3 (13.4–70.6) | 53.2 (24.8–92.5) | 40.6 (19.9–75.5) | 48 (15–105) |
Definition of abbreviations: GAP = gender, age, and physiology; IQR = interquartile range; SD = standard deviation; UUS = United States, United Kingdom, and Spain.
*
Missing data: FVC, n = 6; DlCO, n = 31: GAP stage, n = 6.
†
Missing data: FVC, n = 241; DlCO, n = 264: GAP stage, n = 241.
‡
Missing data: FVC, n = 30; DlCO, n = 41; GAP stage, n = 30.
§
Missing data: FVC, n = 4; DlCO, n = 9; GAP stage, n = 4.