Table 2.
Results for the SNPs Nominally Associated across Stages and with Same Direction of Effects on Idiopathic Pulmonary Fibrosis Survival
| Variant Location (hg19) and Nearest Gene |
Stage I Results |
Stage II Results |
Meta-Analysis |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chr | Position | SNP rsID | Gene | Ref | EA | R 2 | EAF (%) | HR (95% CI) | P Value | EAF (%) | HR (95% CI) | P Value | HR (95% CI) | P Value |
| 2 | 84291167 | rs184498750 | SUCLG1 | G | T | 0.86 | 1.1 | 3.11 (1.88–5.15) | 9.83 × 10−6 | 1.2 | 2.05 (1.79–4.18) | 0.049 | 2.71 (1.79–4.08) | 2.07 × 10−6 |
| 15 | 76081200 | rs60514164 | UBE2Q2 | C | T | 0.77 | 7.0 | 1.60 (1.32–1.95) | 2.35 × 10−6 | 7.7 | 1.42 (1.04–1.93) | 0.026 | 1.55 (1.31–1.83) | 2.23 × 10−7 |
| 15 | 101914234 | rs35647788 | PCSK6 | C | T | 0.93 | 0.8 | 4.76 (2.62–8.64) | 2.96 × 10−7 | 0.8 | 3.12 (1.37–7.11) | 6.72 × 10−3 | 4.11 (2.54–6.67) | 9.45 × 10−9 |
| 19 | 1412985 | rs3893252 | DAZAP1 | C | T | 0.82 | 0.6 | 3.57 (1.97–6.49) | 2.91 × 10−5 | 1.5 | 2.09 (1.05–4.15) | 0.036 | 2.84 (1.81–4.45) | 5.81 × 10−6 |
Definition of abbreviations: CI = confidence interval; DAZAP1 = deleted in azoospermia-associated protein 1; EA = effect allele; EAF = effect allele frequency; HR = hazard ratio; PCSK6 = proprotein convertase subtilisin/kexin type 6; R2 = lowest imputation quality value across studies; Ref = reference allele; SUCLG1 = succinate-CoA ligase GDP/ADP-forming subunit α; UBE2Q2 = ubiquitin-conjugating enzyme E2Q family member 2.