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Synthesis of biphenyloxypropanamide derivatives 35a–35b a. a Reagents and conditions: (a) DMAP, ethyl acrylate, 100 °C, 3 h, 39%; (b) LiOH, THF, H2O, rt, 12 h, 69%; (c) 3-(trifluoromethoxy)aniline, T3P, DIPEA, THF, rt, 12 h, 62%; (d) boronic acids, Pd(PPh3)4, Cs2CO3, 1,4-dioxnae, H2O, 100 °C, 12 h, 60% for 35a and 41% for 35b.
