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In vitro MDH inhibitory activity and cell viability of naphthalene derivatives 39a–d.
| ||||||
|---|---|---|---|---|---|---|
| Compd. | R | R1 | MDH1 IC50 (µM) a |
MDH2 IC50 (µM) a |
Cell Viability IC50 (µM) a |
|
| A549 | H460 | |||||
| 39a | H | H | >5 | >5 | >20 | >20 |
| 39b | Br | H | 1.61 ± 0.25 | >5 | 14.19 ± 0.2 | 14.86 ± 0.07 |
| 39c | H | Br | 1.61 ± 0.21 | >5 | 17.66 ± 0.18 | 14.75 ± 0.18 |
| 39d | H | F | 2.25 ± 0.77 | 18.29 ± 1.8 | >20 | ND |
| LW1497 | 2.24 ± 0.11 | 1.59 ± 0.04 | 7.98 ± 0.53 | 6.14 ± 0.29 | ||
a Values are the means of three experiments.
