Table 3.
Multiple linear regression models for each SARS-CoV-2 variant.
| SARS-CoV-2 % Surrogate Neutralization (Dependent Variable) |
Independent Variables | R2 | β (95% CI) | Adjusted p-value (Holm-Šídák) |
|---|---|---|---|---|
| BA.1 | V1–V2 Interval | 0.8631 | 0.1292 (0.04807 to 0.2104) | 0.0076 |
| V2–V3 Interval | 0.2653 (0.2291 to 0.3015) | 0.0006 | ||
| V3-BC Interval | −0.09670 (−0.1938 to −0.001385) | 0.1339 | ||
| Age | −0.2068 (−0.4396 to 0.02592) | 0.1562 | ||
| Sex (Female) | −3.605 (−8.636 to 1.427) | 0.1597 | ||
| B.1.351 | V1–V2 Interval | 0.9693 | 0.2430 (0.1903 to 0.2957) | 0.0006 |
| V2–V3 Interval | 0.2898 (0.2663 to 0.3134) | 0.0006 | ||
| V3-BC Interval | 0.09856 (0.03607 to 0.1610) | 0.0063 | ||
| Age | −0.1348 (−0.2859 to 0.01637) | 0.0803 | ||
| Sex (Female) | −3.985 (−7.252 to −0.7171) | 0.0337 | ||
| P.1 | V1–V2 Interval | 0.9746 | 0.2424 (0.1939 to 0.2910) | 0.0006 |
| V2–V3 Interval | 0.2862 (0.2645 to 0.3079) | 0.0006 | ||
| V3-BC Interval | 0.1128 (0.05525 to 0.1704) | 0.0006 | ||
| Age | −0.1028 (−0.2420 to 0.03649) | 0.1476 | ||
| Sex (Female) | −3.780 (−6.790 to −0.7700) | 0.0278 | ||
| B.1.1.7 | V1–V2 Interval | 0.9851 | 0.2487 (0.2097 to 0.2878) | 0.0006 |
| V2–V3 Interval | 0.2892 (0.2718 to 0.3066) | 0.0006 | ||
| V3-BC Interval | 0.1397 (0.09337 to 0.1860) | 0.0006 | ||
| Age | −0.06297 (−0.1750 to 0.04905) | 0.2697 | ||
| Sex (Female) | −2.653 (−5.075 to −0.2319) | 0.0626 | ||
| B.1.617.2 | V1–V2 Interval | 0.9837 | 0.2411 (0.2003 to 0.2818) | 0.0006 |
| V2–V3 Interval | 0.2889 (0.2707 to 0.3071) | 0.0006 | ||
| V3-BC Interval | 0.1389 (0.09055 to 0.1872) | 0.0006 | ||
| Age | −0.05231 (−0.1701 to 0.06373) | 0.3714 | ||
| Sex (Female) | −2.863 (−5.391 to −0.3352) | 0.0523 | ||
| WT | V1–V2 Interval | 0.9917 | 0.2514 (0.2211 to 0.2817) | 0.0006 |
| V2–V3 Interval | 0.2844 (0.2709 to 0.2980) | 0.0006 | ||
| V3-BC Interval | 0.1846 (0.1487 to 0.2205) | 0.0006 | ||
| Age | −0.02443 (−0.1113 to 0.06240) | 0.5803 | ||
| Sex (Female) | −2.217 (−4.094 to −0.3402) | 0.0410 |