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. Author manuscript; available in PMC: 2023 Jun 14.
Published in final edited form as: Gastroenterology. 2021 Jul 21;161(5):1567–1583.e9. doi: 10.1053/j.gastro.2021.07.027

Fig. 1: Activation and degranulation of innate immune cells in blood and liver of HDV-infected patients and uninfected controls.

Fig. 1:

(A) Frequency of total (left panel), activated (HLA-DR+, middle panel) and degranulating (CD107a+, right panel) MAIT cells in blood and liver of HDV-infected patients and uninfected controls.

(B) Spearman correlation between the frequency of degranulating CD107a+ intrahepatic MAIT cells and HDV viremia (left panel) and Ishak fibrosis score (right panel) of HDV-infected patients.

(C) Frequency of total (left panel), activated (HLA-DR+, middle panel) and degranulating (CD107a+, right panel) NK cells in blood and liver of HDV-infected patients and uninfected controls.

(D) Spearman correlation between the frequency of activated (HLA-DR+) liver NK cells and HDV viremia (left panel), and the frequency of degranulating (CD107a+) blood NK cells and Ishak fibrosis score (right panel). Median and interquartile range are shown in A and C. Wilcoxon matched pairs signed rank test for comparing paired blood and liver samples of HDV-infected patients, Mann Whitney test for all other comparisons.