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. Author manuscript; available in PMC: 2023 Jun 14.
Published in final edited form as: Gastroenterology. 2021 Jul 21;161(5):1567–1583.e9. doi: 10.1053/j.gastro.2021.07.027

Fig. 3: Most activated and degranulating CD8+ T cells in the liver are tissue-resident.

Fig. 3:

(A) Frequency of HDV-specific CD8+ T cells in liver and blood.

(B) Flt-SNE visualization of the distribution of HDV-specific CD8+ T cells (black dots) relative to total blood (left panel) and liver CD8+ T cells (right panel).

(C, D) Activated (left) and degranulating (right) HDV-specific CD8+ T cells (C) and total CD8+ T cells (D) were assessed for markers of liver residency (CD69 and CXCR6).

Statistics: Wilcoxon matched-pairs signed-rank test, Friedman test with Dunn’s multiple comparisons test. FIt-SNE: Fast Fourier Transform-accelerated Interpolation-based t-Stochastic Neighbor Embedding.