Fig 7. Functional knockout of Bmal1 promotes widespread transcriptomic alterations and activation of multiple oncogenic pathways.

A. Principal Component Analysis (PCA) demonstrating overall differences in expression between WT (green) and BKO (purple) samples (n = 6 each) B. Volcano plot showing genes that were significantly upregulated (red) and downregulated (blue) on differential gene expression (DGE) analysis (q < 0.05). All significant core clock genes are highlighted C. KEGG analysis was then performed, and the top 9 pathways ordered by significance are shown. For each pathway, the size of each dot corresponds to the number of genes involved in each pathway.