Extended Data Figure 3:

(a) Replicate of main figure 3(b) in astrocytes, showing a strong positive relationship between astrocyte module membership, and relative expression in astrocyte cells. (b-e) Relationship between module kME and cell type relative expression for transcripts across 4 neuron/astrocyte isoform switch genes, demonstrating concordance between high kME, and high relative expression. (f) Unsigned Fisher’s exact test of the contingency of “assigned to module” and “top-ranked cell type marker” for varying kME thresholds for (left) oligodendrocytes and (right) astrocytes; for marker rankings based on both absolute and relative expression within the cell-sorted data. Thresholds in the range 0.45–0.55 appear to balance significance and odds ratio across absolute and relative rankings.