Table 2.

MR estimates of the association between gut microbiota and the risk of ALM.

Exposure	Outcome	No. of IVs	Method	OR (95% CI)	P-valuea	Heterogeneity	MR Egger
						Cochran's Q (P-valuea)	Intercept (P-value)
Actinomycetales	ALM	5	IVW	1.029 (1.005, 1.053)	0.017	5.085 (0.279)	0.003 (0.358)
			MR Egger	0.999 (0.943, 1.058)	0.972
			Weighted median	1.015 (0.987, 1.044)	0.278
Actinomycetaceae	ALM	5	IVW	1.029 (1.005, 1.052)	0.016	5.064 (0.281)	0.003 (0.361)
			MR Egger	0.999 (0.943, 1.058)	0.978
			Weighted median	1.015 (0.988, 1.043)	0.275
Bacteroidaceae	ALM	12	IVW	1.041 (1.010, 1.073)	0.008	12.005 (0.151)	0.002 (0.711)
			MR Egger	1.008 (0.852, 1.192)	0.927
			Weighted median	1.022 (0.987, 1.060)	0.215
Porphyromonadaceae	ALM	11	IVW	1.036 (1.002, 1.071)	0.037	13.816 (0.087)	0.005 (0.232)
			MR Egger	0.951 (0.832, 1.086)	0.481
			Weighted median	1.047 (1.010, 1.086)	0.013
Prevotellaceae	ALM	18	IVW	1.034 (1.007, 1.061)	0.012	38.021 (0.001)	0.003 (0.359)
			MR Egger	0.990 (0.902, 1.087)	0.838
			Weighted median	1.018 (0.994, 1.043)	0.142
Bacteroides	ALM	12	IVW	1.041 (1.010, 1.073)	0.008	12.005 (0.151)	0.002 (0.711)
			MR Egger	1.008 (0.852, 1.192)	0.927
			Weighted median	1.022 (0.987, 1.060)	0.223
Eubacterium fissicatena group	ALM	9	IVW	0.983 (0.967, 1.100)	0.044	16.317 (0.038)	0.004 (0.540)
			MR Egger	0.954 (0.870, 1.047)	0.353
			Weighted median	0.978 (0.961, 1.995)	0.010
Marvinbryantia	ALM	12	IVW	1.023 (1.000, 1.046)	0.045	12.223 (0.201)	−0.001 (0.769)
			MR Egger	1.037 (0.946, 1.137)	0.457
			Weighted median	1.033 (1.007, 1.059)	0.013
Phascolarctobacterium	ALM	11	IVW	1.027 (1.001, 1.054)	0.041	14.772 (0.064)	−0.001 (0.888)
			MR Egger	1.037 (0.909, 1.183)	0.603
			Weighted median	1.014 (0.984, 1.042)	0.322

^aBold values indicate P-value < 0.05.