Figure 3.
Primer extension analysis of 10.5 day yolk sac (YS) and 15.5 day fetal liver (FL) RNA from five additional LCR –1348 γ-β CACCC mutant transgenic mouse lines. The high levels of human β-globin RNA in the yolk sac confirm that the γ-globin gene CACCC box is essential for correct β-globin gene developmental specificity.