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. 2022 Dec 19;41(6):794–805. doi: 10.1038/s41587-022-01535-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 10 — a. Phase plots of H3K27ac and ATAC, velocity and expression signal for top 10 most likely velocity driver genes identified by scvelo. b. Heatmap showing ATAC-seq signal normalized with sctransform⁴². Rows depict individual top velocity driver genes, sorted by time of value with maximum intensity and columns depict individual cells sorted by latent time. c. Heatmap showing the chromatin velocity. Rows depict individual top velocity driver genes, sorted by time of value with maximum intensity and columns depict individual cells sorted by latent time. d. Gene ontology enrichment analysis of the most important velocity driver genes. P value was calculated using R package enrichGO, using one sided Fischer’s test with Benjamini-Hochberg correction for multiple hypothesis testing.