Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 19;41(6):794–805. doi: 10.1038/s41587-022-01535-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — a, UMAP embedding of the individual modalities with cluster labels identified through WNN analysis. Embedding is based on individual modalities, whereas cluster identities are assigned from WNN dimensionality reduction. b, Venn diagram showing the overlap of peaks identified from the individual modalities. c,d, UMAP projection and visualization of ATAC, H3K27ac and H3K27me3 signal intensity in single cells at the Foxg1 (c) and Irx2 loci (d). Gray lines connect the cells with same the single-cell barcodes across the different modalities. Clusters for telencephalon astrocytes (AST_TE) and non-telencephalon astrocytes (AST_NT) were selected for the visualization. Aggregated pseudo-bulk tracks for all modalities together with genomic annotations are shown to the right.