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. 2023 Jan 2;41(6):813–823. doi: 10.1038/s41587-022-01560-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — (a) UMAP visualization of H3K4me1 and H3K27me3, lines join H3K4me1 and H3K27me3 UMAPs of double-incubated neutrophils. Heterogeneity within neutrophils are colored as neutrophil pseudotime. (b) H3K4me1 and H3K27me3 modification levels at the Retnlg (a mature neutrophil marker gene) locus along neutrophil pseudotime. (c) H3K4me1 and H3K27me3 modification levels at the Hoxa along neutrophil pseudotime. (d) UMAP of H3K27me3 signal across single cells colored by weights of a topic containing high H3K27me3 levels at many Hox and developmental gene loci (Hox topic). (e) Topic weights of the top 150 genes associated with loci in the Hox topic for H3K27me3. (f) Neutrophil mRNA abundance of genes in the Hox topic compared to other genes derived from publicly available scRNA-seq data²⁵. Number of genes per boxplot: n=17986 for All Genes, n=127 for genes in the Hox topic. Boxplots show 25th percentile, median and 75th percentile, with the whiskers spanning 97% of the data.