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. 2023 Jan 2;41(6):813–823. doi: 10.1038/s41587-022-01560-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — (a) Histogram of unique fragment cuts per cell. (b) Histogram of fraction of unique fragments starting with a "TA" motif. (c) UMAP of H3K4me1 sortChIC data, cells colored by cell type. (d) Assignment plot showing individual H3K4me1+H3K27me3 cells (represented as dots) assigned to a pair of topics (x-axis labels are H3K4me1 clusters, named by their associated cell type, while y-axis are H3K27me3 clusters). Cells along the diagonal are high-confidence predictions that match a H3K4me1 cluster with a H3K27me3 topics, and are colored by the H3K4me1-derived cell type labels. (e) UMAP of H3K4me1+H3K27me3 sortChIC. Cells are colored by their cell type inferred from cluster pairs. Low-confidence predictions are colored in grey. (f, g) UMAP representation of H3K4me1 (f) and H3K27me3 (g). Cells are colored by whether the epigenome was generated by single-incubation or by unmixing by scChIX-seq.