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. 2023 May 25;25(6):877–891. doi: 10.1038/s41556-023-01152-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — a) UMAP representation of gene signature analysis for fatty acid/scavenger receptor genes from GO_term 20220131-155727⁻scavenger_receptors. Analysis of the combined sequence data from unstimulated lung MAIT cells, aaMAIT cells, and these two populations 10 hrs after stimulation with S. pneumoniae, as shown in Fig. 3. b) Effect of etomoxir on the baseline oxygen consumption rate (OCR) as detected by Seahorse Bioanalyzer. Spleen CD8⁺ T cells from mice at day 40 post BRD509 vaccination were analyzed at baseline (Unstim) and when activated (CD3/28) in the presence (ETO) or absence (Ctrl) of etomoxir. Same concentration of ETO as in Fig. 4f–h, showing an on-target effect of the drug. n = 3,5,4 mice per group from one experiment. Two-tailed, unpaired t tests, ***P = 0.00071, ****P < 0.0001. Data displayed as mean ± s.e.m. Source numerical data are available in source data.

Source data