Table 4.

Regression analysis of correlation between death and recurrence with ACC clinico-pathologic parameters

	Total cohort (n = 79)		R0 patients (n = 44)
Variable	Death r/χ2	Recurrence r/χ2	Death r/χ2	Recurrence r/χ2
Necrosis	9.7	21.2	4.7	10.5
	0.002	< 0.001	0.029	0.001
Venous invasion	3.0	10.7	2.1	5.5
	0.085	0.001	0.152	0.019
RMS	11.0	14.5	-	-
(R0/R1)	< 0.001	< 0.001
Age	0.256	0.239	0.261	0.411
	0.024	0.034	0.086	0.006
Tumor size	0.102	0.317	-0.063	0.192
	0.376	0.004	0.687	0.211
Tumor stage	0.343	0.580	0.080	0.448
	0.002	< 0.001	0.605	0.002
Total Weiss score	0.106	0.273	0.064	0.211
	0.352	0.015	0.682	0.170
Ki67 LI	0.157	0.186	0.195	0.008
	0.256	0.179	0.205	0.960
Dichotomized tumor size	5.1	17.7	1.5	9.4
(cut-off 6 cm)	0.024	< 0.001	0.222	0.002
Grouped tumor stage	5.6	15.8	0.45	4.3
(I-II vs III-IV)	0.018	0.000	0.832	0.038
Dichotomized Weiss score	1.6	2.6	0.134	0.6
(cut-off 6)	0.200	0.110	0.714	0.447
Dichotomized Ki67 LI	1.3	1.9	0.049	0.052
(cut-off 20%)	0.248	0.172	0.825	0.820

Necrosis, venous invasion, and resection margin status (RMS) are dichotomized variables (presence or absence); age, tumor size, tumor stage, total Weiss score, and Ki67 labeling index (LI) are considered continuous variables; grouped tumor stage and dichotomized Weiss score, tumor size, and Ki67 LI are non-continuous variables; r/χ² is reported for continuous and categorical variables, respectively; p values are indicated (significant in italics)