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. 2023 Jun 13;6:638. doi: 10.1038/s42003-023-05011-w

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a UMAP of major cell types in the SVF of human omental fat samples split by sex. b Proportion of each cell type in female or male human samples. c UMAP of major cell types in the SVF of mouse perigonadal fat samples split by sex. d Proportion of each cell type in female or male mouse samples. e Heatmap of the top 10 upregulated genes in each cell type for the female vs. male contrasts in humans. f Heatmap of the top 10 upregulated genes in each cell type for the female vs. male contrasts in mice. Values are mean ± SD in (b). n = 4 females and 5 males for (b) and n = 1 pooled sample from n = 10 male mice and n = 1 pooled sample from n = 10 female mice for (d). **p < 0.005 versus male within the same cell cluster. An unpaired t Test was used to compare the means for each cell cluster.