Fig. 4. Schematic diagram illustrating the CDK1-associated mediators in cancer.

CDK1 expression is regulated at either transcriptional or post-transcriptional levels and CDK1 activity is tightly controlled by numerous molecules. Once activated, CDK1 interacts with and phosphorylates a wide variety of proteins serving as oncogenes, tumor suppressors, or substrates in cell cycle. Selective CKIs and pan-CDK1 have been developed and studied in preclinical or clinical evaluation.