Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jun 13;14:3286. doi: 10.1038/s41467-023-38238-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 8 — a Proportion survived in the Framingham Heart Study (FHS) by SAS-1/MAS-1 groupings/profiles calculated at time 0. b Distribution of SAS-1/MAS-1 profiles in the FHS by survival status. c Model: age, sex, and immunologic resilience (IR) levels influence lifespan. d–g Representation of SAS-1/MAS-1 profiles. d Sepsis #1 comprises healthy controls and meta-analysis of patients with community-acquired pneumonia (CAP) and fecal peritonitis (FP) stratified by sepsis response signature groups (G1 and G2 associated with higher and lower mortality, respectively). Sepsis #2 comprises healthy controls and patients with systemic inflammatory response syndrome (SIRS), sepsis, and septic shock survivors (S) and nonsurvivors (NS). e Participants in a natural influenza season cohort (age: 18–49 years) sampled at pre and during acute respiratory infection (ARI) and at spring follow-up: overall (left) or according to the indicated SAS-1/MAS-1 profile during the pre-ARI season (right). P values (asterisks, ns) for participants with SAS-1^low-MAS-1^high at pre-ARI (right) are for their cross-sectional comparison to the profiles at the corresponding timepoints for participants with SAS-1^high-MAS-1^low at pre-ARI (middle). f Schema of the timing of gene expression profiling in experimental intranasal challenges with respiratory viral infection in otherwise healthy young adults with data presented in panels g and h. T, time. g Participants inoculated intra-nasally with respiratory syncytial virus (RSV), rhinovirus, or influenza virus stratified by symptom status and sampling timepoint. Symp. symptomatic, Asymp. asymptomatic. h Participants inoculated intra-nasally with influenza virus stratified by symptom status and sampling timepoint. i Individuals with severe influenza infection requiring hospitalization collected at three timepoints, overall, and by age strata and severity. Patients were grouped by increasing severity levels: no supplemental oxygen required, oxygen by mask, and mechanical ventilation. Cohort characteristics and sources of biological samples and gene expression profile data are in Supplementary Data 13a. *P < 0.05; **P < 0.01; ***P < 0.001; ns nonsignificant. Two-sided tests were used. Statistics are outlined in Supplementary Information Section 11.3.8., P values are in Supplementary Data 14, and Source data are provided as a Source Data file.