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. 2023 Jun 13;13:9595. doi: 10.1038/s41598-023-35615-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Srr expression in Lhx6 + cortical interneuron precursors. (A–C) mRNA for SR (Srr; magenta) and GluN1 (Grin1; cyan) are highly expressed in Lhx6 + intermediate interneuron (green) cells at embryonic day 16 (E16; medial ganglionic eminence (MGE), intermediate zone (IZ), cortical plate (CP)). (D) Pie chart represents the percentage of Lhx6 + cells that express Srr and Srr/Grin1 in E16 IZ (n = 3; two sections per animal). (E) SR and Grin 1 mRNA expression in postnatal day 9 (PND9) PrL (F) Pie chart represents the percentage of Lhx6 + cells expressing Srr and Grin1 in PND9 and PND16 PrL (n = 2; two sections per animal). (G) High-performance liquid chromatography (HPLC) analysis showing l-serine and d-serine content in E15 forebrain tissue (n = 6–10). (H) No immunoreactivity when only d-serine antibody is excluded. (I) Strong d-serine immunoreactivity (brown) in the IZ migratory stream in E15 forebrain. Scale bar = 100 or 20 µm (H–I) and 10 or 25 µm (A–B). N = Bars represent mean ± SEM.