Table 2.
Univariate Cox Proportional Hazards Regression Analysis in Patients with “driver gene-negative” LUAD
| Characteristic | Univariate analysis | ||
|---|---|---|---|
| Hazard ratio | 95% CI | p value | |
| Gender | |||
| Male | Reference | ||
| Female | 1.06 | 0.94–0.65 | 0.81 |
| Age | 1.04 | 1.02–1.06 | < 0.001* |
| ≤ 60 | Reference | ||
| 61–69 | 3.12 | 1.67–5.79 | < 0.001* |
| ≥ 70 | 6.36 | 3.05–13.27 | < 0.001* |
| Smoking status | |||
| No | Reference | ||
| Yes | 1.17 | 0.65–2.11 | 0.59 |
| Stage | |||
| I | Reference | ||
| II | 1.10 | 0.62–1.94 | 0.75 |
| III | 4.31 | 2.21–8.40 | < 0.001* |
| Degrees of differentiation | |||
| High | Reference | ||
| Moderate | 1.15 | 0.35–3.71 | 0.82 |
| Low | 1.19 | 0.32–4.33 | 0.79 |
| CTC count | |||
| < 4 | Reference | ||
| ⩾4 | 2.62 | 1.59–4.33 | < 0.001* |
| PD-L1 expression | |||
| Low | Reference | ||
| High | 1.52 | 0.86–2.72 | 0.15 |
| Rad-score | 3.18 | 1.97–5.15 | < 0.001* |
LUAD lung adenocarcinoma, CI confidence interval, CTC circulating tumor cell, SD standard deviation, PD-L1 programmed death ligand-1, Rad-score radiomics score
*statistically significant p value