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Objective response characteristics for IO score, TMB, and IO + /TMBhigh
| Biomarker | IO score | TMB high | IO + /TMBhigh |
|---|---|---|---|
| DCR for biomarker ( +) (PPV) | 52% (14/27) | 69% (11/16) | 53% (17/32) |
| DCR for biomarker (-) | 13% (6/46) | 16% (9/57) | 7% (3/41) |
| Odds ratio for DCR | 7.18 (95%CI 2.3–22.5; p = 0.0007) | 11.73 (95%CI 3.3–42.0; p = 0.0002) | 14.36 (95%CI 3.7–56.2; p = 0.0001) |
| NPV | 87% (40/46) | 84% (48/57) | 93% (38/41) |
